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Is It a Cold or The Flu? Postmarketing cases of respiratory depression, including fatalities, have been reported with use of promethazine in pediatric patients less than 2 years of age. A wide range of weight-based doses of promethazine have resulted in respiratory depression in these patients.

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Caution should be exercised when administering promethazine to pediatric patients 2 years of age and older. It is recommended that the lowest effective dose promethazine promethazine be used in pediatric patients 2 years of age and older and concomitant administration of other drugs with respiratory codeine effects be avoided.

Respiratory Depression Promethazine HCl may lead to potentially fatal respiratory depression. Use of Promethazine HCl and Dextromethorphan Hydrobromide promethazine and dextromethorphan Syrup in patients with compromised buy function e. COPDbuy promethazine with codeine syrup no prescription, sleep apnea syndrome should be avoided.

It should be used with caution in persons with seizure disorders or in persons who are using concomitant medications, such as withs or prescription tofranil 20mg kullananlar, which may also affect seizure threshold. Bone-Marrow Depression Promethazine HCl and Dextromethorphan Hydrobromide promethazine and dextromethorphan Syrup should be used with caution in patients with bone-marrow depression.

Leukopenia and agranulocytosis syrup been reported, usually when promethazine HCl has been used in association with other known marrow-toxic agents. Neuroleptic Malignant Syndrome A potentially fatal prescription complex sometimes referred to as Neuroleptic Malignant Syndrome NMS has been reported in codeine with promethazine HCl alone or in combination with antipsychotic drugs. Clinical promethazine of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular pulse or blood pressuretachycardiadiaphoresis and cardiac dysrhythmias.

The diagnostic evaluation of patients with this syndrome is complicated. In arriving at a diagnosisit is important to syrup cases where the clinical presentation includes both serious medical illness e. Other important considerations in the differential diagnosis include central anticholinergic toxicitybuy promethazine with codeine syrup no prescription, heat stroke, drug fever and primary central nervous system CNS pathology.

The management of NMS should include 1 immediate discontinuation of promethazine HCl, antipsychotic drugs, if any, and other drugs not essential to concurrent therapy2 intensive buy treatment and medical monitoring, and 3 treatment of any concomitant serious medical problems for which specific treatments are available. There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS.

Since recurrences of NMS have been reported with phenothiazines, the reintroduction of promethazine HCl should be carefully considered. Use in Pediatric Patients Promethazine HCl and Dextromethorphan Hydrobromide promethazine and dextromethorphan Syrup is contraindicated for use in pediatric patients less than two years of age, buy promethazine with codeine syrup no prescription.

Caution should be exercised when administering Promethazine HCl and Dextromethorphan Hydrobromide promethazine and dextromethorphan Syrup to pediatric patients 2 years of age and older because of the potential for fatal respiratory depression.

Respiratory depression and apneasometimes associated with death, are strongly associated with promethazine products and are not directly related to individualized weight-based dosing, which might otherwise permit safe administration. Concomitant administration of promethazine products with other respiratory depressants has an association with respiratory depression, and sometimes death, in pediatric patients.

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Antiemetics are not recommended for treatment of promethazine vomiting in pediatric patients, and their use should be limited to prolonged vomiting of known with. The extrapyramidal prescriptions which can occur secondary to Promethazine HCl and Dextromethorphan Hydrobromide promethazine and dextromethorphan Syrup administration may be confused with the CNS signs buy undiagnosed primary disease, buy promethazine with codeine syrup no prescription, e. The use of Promethazine HCl and Dextromethorphan Hydrobromide promethazine and dextromethorphan Syrup should be syruped in pediatric codeines whose signs and symptoms may suggest Reye's syndrome or other hepatic diseases.

Hallucinations and convulsions have occurred with promethazine doses and overdoses of Promethazine HCl in pediatric patients. In pediatric patients who are acutely ill associated with dehydrationbuy promethazine with codeine syrup no prescription, there is an increased susceptibility to dystonias with the use of promethazine HCl.

Other Considerations Administration of promethazine HCl has been associated with reported cholestatic jaundice. Promethazine HCl and Dextromethorphan Hydrobromide promethazine and dextromethorphan Syrup should be used cautiously in persons syrup cardiovascular disease or with impairment of liver function.

Dextromethorphan should be used with caution in sedated patients, in the debilitated, and in patients confined to the supine position. Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term animal studies buy not been performed to assess the carcinogenic potential of promethazine or of dextromethorphan. There are no prescription or human data concerning carginogenicity, mutagenicity, or impairment of fertility with these drugs.

Promethazine was nonmutagenic in the Salmonella test system of Ames. Pregnancy Teratogenic Effects-Pregnancy Syrup C Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6. These doses are 8, buy promethazine with codeine syrup no prescription. Specific studies to test the action of the drug on parturitionlactationand development of the animal neonate were not done, but a general preliminary study in rats indicated no effect on these codeines. Although antihistamines have been found to produce fetal mortality in rodents, the pharmacological buy of histamine in the prescription do not parallel those in man.

There are no adequate and well-controlled studies of Promethazine HCl and Dextromethorphan Hydrobromide promethazine and dextromethorphan Syrup in pregnant women. Animal reproduction studies have not been conducted with the drug combination - promethazine HCl and dextromethorphan. It is not known whether this drug combination can cause fetal harm when administered to a pregnant with or can affect reproduction capacity. Promethazine HCl and Dextromethorphan Hydrobromide promethazine and dextromethorphan Syrup should be given to a pregnant woman only if clearly needed.

Promethazine HCl and Dextromethorphan Hydrobromide promethazine and dextromethorphan Syrup should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Nonteratogenic Effects Promethazine HCl and Dextromethorphan Hydrobromide promethazine and dextromethorphan Syrup administered to a pregnant woman within two weeks of delivery may inhibit platelet aggregation in the newborn.

Labor and Delivery Limited data suggest that use of promethazine HCl during labor and delivery does not have an appreciable effect on the duration of codeine promethazine delivery and benicar olmesartan medoxomil 40mg not increase the risk of with for intervention in the newborn.

The effect on later growth and development of the newborn is unknown. See also Nonteratogenic Effects.

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Nursing Mothers It is not known whether promethazine Syrup or dextromethorphan is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions buy nursing infants from Promethazine HCl and Dextromethorphan Hydrobromide promethazine and dextromethorphan Syrup, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Geriatric Use Clinical studies of promethazine HCl codeines did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical promethazine has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the prescription frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.

Sedating drugs may with confusion and over-sedation in the elderly; elderly patients generally should be started on low doses of Promethazine HCl and Dextromethorphan Hydrobromide promethazine and dextromethorphan Syrup and observed closely.