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Clinical Studies Hypertension In controlled clinical studies, Lopressor has been shown to be an effective antihypertensive 50mg when used alone or as concomitant therapy with thiazide-type diureticst metoprolol 50mg, at oral dosages of mg daily.
In controlled, comparative, clinical studies, Lopressor has been shown to be as effective an antihypertensive agent as propranolol, methyldopa, and thiazide-type diuretics, to be metoprolol effective in supine and standing positions.
Angina Pectoris In controlled clinical trials, Lopressor, administered orally 50mg or four times metoprolol, has been shown to be an effective antianginal agent, reducing the number of angina attacks and increasing exercise tolerance.
The oral dosage used in these studies ranged from mg daily. A controlled, comparative, t metoprolol 50mg, clinical trial showed that Lopressor was indistinguishable from propranolol in the treatment of angina pectoris.
Patients were randomized and treated as soon as possible after their arrival in the hospital, once their clinical condition had stabilized and their hemodynamic status had been carefully evaluated.
Initial treatment consisted of intravenous followed by oral administration of Metoprolol or placebo, given in a coronary care or comparable unit.
Oral maintenance therapy with Lopressor or placebo was 50mg continued for 3 months. After this double-blind period, all patients were given Lopressor and followed up to 1 year, t metoprolol 50mg.
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The median delay from the onset of symptoms to the initiation of therapy was 8 hours in both the Lopressor- and placebo-treatment groups. Significant reductions in the incidence of ventricular fibrillation and in chest pain following initial intravenous therapy were also observed with Lopressor and were independent of the interval between onset of symptoms and initiation of therapy.
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In this study, patients treated with metoprolol received the drug both very early intravenously and during a subsequent metoprolol period, t metoprolol 50mg, while 50mg patients received no beta-blocker treatment for this period, t metoprolol 50mg.
The study thus was able to show a benefit from the overall metoprolol regimen but cannot separate the benefit of very early intravenous treatment from the benefit of later beta-blocker therapy.
Nonetheless, because the overall regimen showed a clear beneficial effect on survival without evidence of an early adverse effect on survival, one acceptable dosage regimen is 50mg precise regimen used in the trial.
Because the specific benefit of metoprolol early treatment remains to be defined however, it is also reasonable to administer the drug orally to patients at a later time as is recommended for certain other beta blockers.
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